| 24160 |
Affinity Measurement |
2 to 3 weeks |
Request
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Scope:
· Kinetics analysis/affinity measurement of samples using biolayer interferometry (BLI) or surface plasmon resonance (SPR) · Deliverables include data summary with processed data (Ka, Kd and KD) and sensorgrams. · High throughput and Off-rate ranking studies available?
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| 1018 |
Epitope Binning |
2 to 4 weeks |
Request
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Scope:
· Competitive immunoassay to assess binding of two antibodies to a target sequentially. In-tandem, Classic ?sandwich, and premix methodologies available.
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| 24190 |
Fc-gamma Receptor Panel Binding Assay |
1 to 2 weeks |
Request
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Scope:
· Assess binding affinity of Fc fusion proteins or antibodies · Full Fc panel includes Fc?RI, Fc?RIIA, Fc?RIIB, Fc?RIIIA-158F, Fc?RIIIA-158V, and FcRn (pH 6.0 and pH 7.2) · In-house control antibody included · Customized pricing available
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| 24701 |
In Silico Immunogenicity Prediction |
4 to 5 days |
$ 1,100
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Scope:
· Variable heavy and variable light chain sequences are analyzed and nice core residues with potential affinity to the binding cleft of MHC class II molecules are identified.
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| 24700 |
Sequence Liability Identification |
4 to 5 days |
$ 1,100
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Scope:
· Heavy and light chain variable region liability analysis · VH and VL analysis with identification of core residues with potential affinity to MHC class II · Heavy and light chain variable region liability analysis including but not limited to N-linked glycosylation, deamidation, isomerization, pyroglutamate formation, and oxidation.
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| 2000 |
Developability package -2 |
Custom |
Request
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Scope:
· Polyspecificity Assessment · Integrity and Stability Assessment of the concentrated sample · Accelerated Stress Assessment
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| 3000 |
Developability package -3 |
Custom |
Request
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Scope:
· Formulation and Stability Testing Package Workflow · Buffer formulations · Stress Conditions · Assays
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